The rotenone model of parkinsonism--the five years inspection.

The effect of low dose amphetamine in rotenone-induced toxicity in a mice model of Parkinson’s disease

Objective(s): The effects of low dose amphetamine on oxidative stress and rotenone-induced neurotoxicity and liver injury were examined in vivo in a mice model of Parkinson’s disease. Materials and Methods: Male mice were treated with rotenone (1.5 mg/kg, every other day for two weeks, subcutaneously). Mice received either the vehicle or...

Protective Role of Alternanthera Sessilis (Linn.) Silver Nanoparticles and Its Ethanolic Extract against Rotenone Induced Parkinsonism

Biosynthesis of nanoparticles incorporating the herbal extracts can potentially eliminate the toxicity problem. Green synthesis of silver nanoparticles was done by using the ethanolic extract of Alternanthera sessilis (Linn.) and Silver nitrate. The anti-parkinsonism activity of ethanolic extract of Alternanthera sessilis (Linn.) (EEAS) and its silver nanoparticles (ASAgNPs) was evaluated using...

Controversies on new animal models of Parkinson's disease pro and con: the rotenone model of Parkinson's disease (PD).

A general complex I deficit has been hypothesized to contribute to neurodegeneration in Parkinson's disease (PD) and all toxins used to destroy dopaminergic neurons are complex I inhibitors. With MPTP or 6-OHdopamine, this hypothesis can not be tested since these toxins selectively accumulate in the dopaminergic neurons. However with rotenone, which penetrates all cells, the hypothesis can be t...

Commentary: Adenosine A2A Receptor Blockade Prevents Rotenone-Induced Motor Impairment in a Rat Model of Parkinsonism

Estrogen agonist genistein differentially influences the cognitive and motor disorders in an ovariectomized animal model of Parkinsonism

Objective(s): Parkinson's disease (PD) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. Evidence indicates that PD occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. It is reported that soy genistein, an estrogen agonist phytoestrogen, display neuroprote...